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China, intervention on the DNA of a human embryo. "So we corrected Mediterranean anemia"

The experts used the "base editing", the evolution of the Crispr technique. In the future, many illnesses may occur ">

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China, intervention on the DNA of a human embryo. "So we corrected Mediterranean anemia"
LONDON - It's like correcting a spelling mistake in a task: put letter A where someone, by mistake, had written G. But correction takes place in DNA of a human embryo and eliminates a serious genetic disorder: hence baby's future, instead of being born ill, will be born healthy. To accomplish this new genetic engineering intervention was a team of doctors in China whose experiment is now published by British scientific journal Protein and Cell and is reported this morning by BBC. Experts have intervened in a case of beta-thalassemia, median anemia, caused by change of a single base in genetic code. "An ingenious step," professor Robin Lovell-Badge of Francis Crick Institute in London, largest biomedical center in Europe. In future, it may be possible to correct similar illnesses in same way. The practical use of such a technique is, however, still far off. It is a turning point that opens up controversial ethical implications, letting us imagine a world in which we could all be more than just healthy, but even more beautiful, at discretion of surgeon and perhaps by paying necessary figures. And now, as scientist at Crick Institute observes, Chinese researchers' initiative raises questions: why have y no longer experimented with animals instead of going directly to human embryos? Standards for human embryo experiments in Europe, America and or countries would also have been stricter with similar interventions. What is allowed in China would not necessarily be in West. READ THE ELENA DUSIMA DIY genetic revolution What exactly did Professor David Liu, one of pioneers of this technique when he taught at Harvard, and his team of Sun Yat-sen University researchers in Guangzhou ? Chinese scientists have used tissues from a patient with beta-thalassemia, also referred to as Mediterranean anemia, a blood disease, and human embryos obtained through cloning. The embryos, to be precise, were not implanted after "correction" experiment. The technique used is that of "base editing", an intervention based on DNA, which consists of four basic blocks, adenine, cytosine, guanine and thymine, each commonly identified by a letter: A, C, G and T. All instructions for building human body are coded in a combination of se four letters. Beta-thalassemia, Mediterranean anemia, a potentially fatal disease, is caused by change of a single base in genetic code, a so-called mutation. Chinese scientists have brought it to right and original version. They scanned DNA to find mistake and n converted G to A. "We were first to demonstrate possibility of curing genetic diseases in human embryos with this technique," says Dr. Junjiu Huang, one of researchers. The "editing base" is a furr development of a form of genetic correction known as Crispr, which is already revolutionizing science. Professor Liu argues that new technique is more effective and has fewer side effects unwanted compared to Crispr. As it is, study released on Protein and Cell, BBC, is latest example of increasing scientists' ability to manipulate human DNA. Introducing a new frontier of medicine.


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